Marijuana and Epilepsy

Posted on May 25th, 2022 to Uncategorized

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Cannabis is known by many names – the most common is marijuana. Cannabis is the Latin name used most often by botanists and pharmaceutical companies. The word marijuana usually refers to the leaves and female flowers of the cannabis plant. Medical cannabis is whole plant marijuana or chemicals in the plant used for medical purposes.

Marijuana was used to treat a variety of conditions in ancient China as far back as 2,700 B.C. They included:

There is also evidence it was used in medieval times to treat:

  • Nausea
  • Vomiting
  • Epilepsy
  • Inflammation
  • Pain
  • Fever

Many people suffering from epilepsy say marijuana stops their seizures, but there is little scientific evidence.

Researchers must apply for a special license from the Drug Enforcement Administration in order to study marijuana.

They need permission to access to a supply kept by the National Institute for Drug Abuse. These challenges have slowed research.

How it works

Both THC and CBD are in a group of substances called cannabinoids. They bind to receptors in the brain and are effective against pain associated with conditions like multiple sclerosis and HIV/AIDS.

 By attaching to receptors, they block the transmission of pain signals. CBD binds to more than just pain receptors.

It appears to work on other signaling systems within the brain and has protective and anti-inflammatory properties.

Exactly how it works in epilepsy isn’t fully understood. While some found CBD was effective against seizures, others did not.

This may be due to the way the drug was given, since some methods work better than others.

Long-Term Prognosis for Epilepsy

Epilepsy is a type of neurological disorder known for causing seizures. These seizures can be sporadic and occur without warning, or they might be chronic and occur on a regular basis.

 Preventing seizures can also help keep you and others safe during a sudden episode while walking, driving, or any other activity.

Despite treatment, premature mortality is increased in people with epilepsy. There are a variety of factors that determine epilepsy prognosis. Among these include you’re:

  • Age
  • Health history
  • Genes
  • Severity or pattern of seizures
  • Current treatment plan

Factors affecting Prognosis

Other factors that can affect your overall prognosis include:

  • Age: Adults over the age of 60 may experience an increased risk for epileptic seizures, as well as related complications.
  • Family history: Epilepsy is often genetic. If you have a family member who experienced epilepsy-related complications, then your own risk may be higher.
  • Infections: These can increase your risk for more seizures, especially brain infections.
  • Preexisting neurological issues: Conditions that include infections, brain trauma, or tumors and autism can all increase the risk of epilepsy.
  • Vascular disorders: Heart diseasestroke, and other vascular disorders can adversely affect your brain. In turn, this can lead to more seizures and subsequent brain damage. You can help minimize this risk factor by adopting heart-healthy lifestyle habits, such as regular exercise and a low-fat/low-sodium diet.

Treatment is one of the most important factors that affect your overall epilepsy prognosis. Ant seizure medication, when taken on a regular basis, can help control activity in the brain that leads to epileptic seizures.

 In turn, this helps to also minimize risk factors and complications related to epilepsy. Some people eventually stop taking ant seizure medications. This mostly occurs if you’ve been seizure-free for at least two years.

Epilepsy can develop at any age. Early childhood and older adulthood tend to be the most common life stages. The outlook tends to be better for people who develop epilepsy as children there’s a chance they might outgrow it as they age. Developing epilepsy before the age of 12 increases this positive outcome,

Epilepsy complications

Common complications from epilepsy may include:

  • Automobile accidents: A seizure could happen at any time — even when you’re on the road. If you have chronic seizures, you might consider another method of travel, such as having a friend or loved one drive for you.
  • Drowning: The Mayo Clinic estimates that people with epilepsy are up to 19 times more likely to drown than people who don’t have the disorder. Drowning can happen while swimming or bathing.
  • Emotional challenges: Epilepsy can be emotionally overwhelming. Some epilepsy medications can also cause side effects that can affect your emotional well-being. Talk to your doctor if you’re experiencing anxiety, depression, or suicidal thoughts. There are treatments and therapies that can help.
  • Falls: You can also be at risk of falling if a seizure strikes while you’re walking or engaging in other activities while standing up. Depending on the severity of the fall, broken bones and other serious injuries may be possible.
  • Inflammation of the liver: This is caused by ant seizure medications.
  • Pregnancy issues: Pregnant women can’t take ant seizure medications because of possible birth defects, yet seizures can also pose dangers to babies. The best way to prevent pregnancy-related complications is to plan ahead — talk to your doctor about your plans beforehand.
  • Status epileptic’s: This is a serious complication that’s a result of numerous, recurring seizures. You might have back-to-back seizures that might last for five minutes or longer at a time. Status epileptics’ is an especially dangerous epilepsy complication because it can cause permanent brain damage. Death is also a possibility.
  • Weight gain: Certain ant seizure medications can make weight loss and management more challenging. Being overweight can then increase your risk for other chronic health problems.

Finally, there’s another possible complication, though relatively rare. It’s called sudden unexplained death in epilepsy (SUDEP).

Childhood is one of the most common life stages when people develop epilepsy. Still, children aren’t as prone to some of the same complications compared with adults.

Some children can possibly outgrow the disorder as they get older. The reasons behind this aren’t fully understood.

Does cannabis have Medical side effects?

Marijuana or cannabis in general has a number of side effects depending on how it is used. For example, if smoked, the negative effect of smoking on a person’s lungs and heart also apply to marijuana.

It is important to know that even though marijuana is a plant, it is broken down in a person’s liver like many medicines. People mistakenly believe that marijuana is completely safe because it is a plant or oil from a plant. However, medication interactions can occur.

The safety data from the trials in people with Lennox-Gas taut syndrome and Dravet syndrome has shown similar side effects. Tiredness, diarrhea, and upset stomach are reported the most. Interestingly, people getting the placebo also reported diarrhea and upset stomach feeling as well. This may be due to both products being oil.

Should a person with epilepsy pursue medical cannabis?

When conventional treatments do not work to control seizures, as is the case for roughly 30% of people with epilepsy, it is not unreasonable to consider CBD oil.

However, this should only be considered after a thorough evaluation at a specialized epilepsy center to look at whether all possible treatments (including FDA-approved new and add-on medicinesdietary therapydevices, and surgery) have been reasonably tried.

Understanding epileptic Seizures  

A seizure is caused by an imbalance in your brain chemistry that produces abnormal jolts of electrical activity. This electrical activity sends impulses throughout your body and causes your muscles to spasm.

Epilepsy is the most common type of seizure disorder, but not all seizures are caused by epilepsy. 

What type of CBD is best for epilepsy?

CBD for Epilepsy

CBD can help treat various health problems, with the best CBD oil can be found here. While many drugs can treat epilepsy, none are known to prevent its development. A third of people with epilepsy remain resistant to their medications.

This leaves them open to increased risk of sudden unexpected death from epilepsy-related seizures or impairments in psychosocial, behavioral, and cognitive functions. This resistance to traditional medications makes CBD products very appealing as an alternative treatment modality.

The interaction between CBD and other epileptic medications is unknown and may be responsible for the elevated liver enzymes seen in some studies of Epidiolex. (FDA’s approved CBD drug for epilepsy).

 However, such adverse effects were not severe and precautions were issued with recommendations to monitor the liver enzymes and concurrent medication levels while using CBD. Otherwise, CBD is generally considered safe, non-psychoactive, with few side-effects. 

What is the U.S. FDA approved Epidiolex?

Food and Drug Administration approved Epidiolex (cannabidiol) [CBD] oral solution for the treatment of seizures associated with tuberous sclerosis complex (TSC) in patients one year of age and older.

Epidiolex was previously approved for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gas taut syndrome (LGS) and Dravet syndrome (DS). This is the only FDA-approved drug that contains a purified drug substance derived from cannabis. It is also the second FDA approval of a drug for the treatment of seizures associated with TSC.

TSC is a rare genetic disease that causes non-cancerous (benign) tumors to grow in the brain and other parts of the body like the eyes, heart, kidneys, lungs, and skin.

TSC usually affects the central nervous system and can result in a combination of symptoms including seizures, developmental delay, and behavioral problems, although the signs and symptoms of the condition, as well as the severity of symptoms, vary widely. TSC affects about 1 in 6,000 people.

The most common side effects that occurred in Epidiolex-treated patients with TSC in the clinical trial were: diarrhea elevated liver enzymes, decreased appetite, sleepiness, fever, and vomiting. Additional side effects for patients with LGS, DS, or TSC include: liver injury, decreased weight, anemia, and increased Creatinine.

Most cases were generally mild, but a risk of rare, but more severe liver injury exists. More severe liver injury can cause nausea, vomiting, abdominal pain, fatigue, anorexia, jaundice, and/or dark urine. 

 

 

 

 

 

 

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